Can the flow direction on this type of globe valve be in either direction?  The service is liquid oxygen with this valve located on the upstream side of the liquid oxygen vaporizers.  There is a flow arrow on the side of the valve, but why would it matter if the flow is pushing up on the disc or down on the disc?

Discuss the specific globe valve model for review with the manufacturer.  If this is a traditional globe valve, the velocity between the plug and seat can cause a bath-tub stopper affect that slams the plug into the seat due to reduced pressure when operating less than 10% travel.  This may not be an issue if the valve is balanced like a cage valve.  Many globe style valves have a recommended orientation and work satisfactorily in both directions.

A Piston Actuator can be used in a unbalanced trim to counter Bath Tub Stopper effect instead of standard Spring & Diaphragm actuators. However if your liquid is cavitating and valve manufacturer uses a muli Hole anti cavitation cage, the flow to be happen over the plug. They ideally want to flow the liquid from outside the cage to inside allowing liquid streams to bombard each other for killing the high energy.

Typically, trim designed for flashing service is similar to compressible flow trims, not incompressible such as liquid and cavitation trims.  With anti-cavitation trims, the vapor bubbles are maintained in the inner cavity so their collapse is located away from the trim solid parts susceptible to cavitation damage; however, for flashing service, the vapor fraction is sustained in the flow.

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